83-5594-59 CCRF-CEM Cells 1vial 300147
特徴
- 概要：CCRF-CEM cells are a type of human T lymphoblasts commonly used in immuno-oncology and immunology research.
- These cells were isolated from the peripheral blood of a 4-year-old female Caucasian with acute lymphoblastic leukemia (ALL).
- CCRF-CEM grow in suspension and can reach high cell density when cultured in spinner flasks.
- Karyotype analysis of CCRF-CEM cells showed a modal number of 47 chromosomes, ranging from 41 to 95.
- They show no consistent loss or gain of specific chromosomes and no marker chromosomes.
- However, 28% of cells with 45 chromosomes showed C- and 53% of all cells had an extra D, and 35% had an additional F.
- CCRF-CEM cells are tumorigenic and can cause tumours in Syrian hamsters.
- These cells express CD3, CD5, CD7, and CD4 genes and antigens.
- Additionally, isoenzyme analysis showed ADA, 1| ES-D, 1| G6PD, B| GLO-I, 1| PEP-D, 1| PGD, C| PGM1, 1| PGM3, 0.
- These cells are reported to be free of virus particles as determined by electron microscopy.
- A study has shown that the combination of resveratrol and prednisolone induced apoptosis in CCRF-CEM cells in a time- and dose-dependent manner.
- The combination treatment showed synergistic effects on the overexpression of BAx and the downregulation of BCL2.
仕様
- 容量：1vial
- カテゴリー： Leukemia cell lines
- Organism：Human
- Tissue：Peripheral blood
- Disease：Leukemia
- Synonyms：CCRF/CEM, CCRFCEM, CCRF.CEM, CCRF CEM, CCRF, CEM, CEM-CCRF, CEM-CCRF (CAMR), CCRF/CEM/0, CEM/0, CEM-0, CCRF-CEM/S, GM03671, GM03671C
- Age：4 years
- Gender：Female
- Ethnicity：Caucasian
- Morphology：Polymorph cells, big nuclei, formation of microvilli
- Cell Type：T lymphoblast
- Growth Properties：Suspension
- Citation：CCRF-CEM (Cytion catalog number 300147)
- Biosafety Level：1
- Protein Expression：p53 negative
- Antigen Expression：CD3 B (37%), CD4 (50%), CD5 (95%), CD7 (77%)
- Isoenzymes：G6PD, B
- Tumorigenic：Yes, in nude mice
- Viruses：EBV negative
- Reverse Transcriptase：negative
- Ploidy Status：Aneuploid
- Msi Status：Instable (MSI)
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