83-5594-51　K562 Cells 1vial　300224

特徴

• 概要：The K562 cell line, originating from the bone marrow of a 53-year-old female with chronic myelogenous leukemia, serves as a cornerstone in various research fields such as immunology, tumor immunology, and the broader scope of immune system disorder research.
• Human K-562 cells are widely used in studies involving immune system interactions, particularly with effector cells like natural killer (NK) cells.
• This is due to their unique characteristics, such as the expression of specific antigens that can be recognized by NK cells.
• Exploring the interaction between NK cells and cancerous cell lines like K562 offers insights into immune defense mechanisms.
• NK cells ability to recognize and respond to K562 cells varies with the presence of specific markers, which fluctuate throughout the K562 cell cycle.
• PLB985 cells are used alongside K562 for comparative studies in hematopoiesis, with the addition of ml bFGF enhancing cell line growth and viability.
• Analyzing normal ABL transcripts in K562 cells sheds light on leukemias molecular dynamics and immune evasion strategies, while also considering the indirect effects on erythrocytes, highlighting the intricate connections between hematological health and disease.
• K562 cells are instrumental in understanding the cell cycle, specifically through cell cycle analysis and observing cell cycle distributions, distributions, which is critical in assessing the impact of abl gene expression and the subsequent decrease in abl fusion transcripts.
• The K562 cell lines utility in assays, particularly those evaluating the cytotoxicity of fgfr inhibitors and the activity of enzymes of epigenetics, underscores the role of the human cells K562 in elucidating cell signaling pathways and the mechanisms of action of various therapeutic agents.
• The human K562 cell line is employed in advanced techniques like 3D cell culture, providing a dynamic environment to study cellular interactions and the effects of diluted peptides and fibroblast growth factors on cell populations.
• Furthermore, K562 cells relevance in leukemia research is amplified by its representation in the leukemia cell line panel, offering a comprehensive pharmacology reference for studying the effects of hydrogen peroxide, the role of the Philadelphia chromosome, and the suppression of prdx6.
• The technical challenges associated with maintaining frozen cells, managing enzyme activity, and conducting immune assays with natural killer cells highlight the cell lines versatility and its contribution to the field, from basic research to translational applications in combating chronic myelogenous leukemia.