特徴
- 概要:This breast tumor line was established by E.Y.
- Lasfargues and L.
- Ozzello in 1958 by isolation and cultivation of cells spilling out of the tumor when it was cut in thin slices.
- TNF-alpha (tumor necrosis factor alpha) inhibits the proliferation of BT-20 cells.
- BT-20 cells are negative for estrogen receptor, but express an estrogen receptor mRNA that has deletion of exon 5.
仕様
- 容量:1vial
- カテゴリー: Breast cancer cell lines
- Organism:Human
- Tissue:Breast, mammary gland
- Disease:Invasive ductal carcinoma
- Synonyms:BT 20, BT20
- Age:74 years
- Gender:Female
- Ethnicity:Caucasian
- Morphology:Epithelial-like
- Growth Properties:Monolayer, adherent
- Citation:BT-20 (Cytion catalog number 300130)
- Biosafety Level:1
- Antigen Expression:HLA A1, Bw16 (+/-)
- Isoenzymes:PGM3, 1, PGM1, 1, ES-D, 1, AK-1, 1-2, G6PD, B, GLO-1, 1-2, Phenotype Frequency Product: 0.0115
- Oncogenes:wnt4 +, wnt7h +
- Tumorigenic:Yes, in nude mice. Forms grade II adenocarcinomas
- Reverse Transcriptase:negative
- Mutational Profile:TP53 mut
- Karyotype:modal number = 50, many markers with large subtelocentrics most characteristic. (P87) Hyperdiploid with abnormalities including fragmented chromosomes, breaks, secondary constrictions, translocations, submetacentric and telocentric markers
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