Dxd （Exatecan ADC derivative） is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs （DS-8201A）.
Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC （Dxd as payload） had no inhibitory effect on HER2 expression in the 4 cell lines.
DS8201a （Dxd as payload） had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 （IC50, ＞ 10000 - mL）.
HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody.
It can be used in PK, PD analysis and ELISA.
仕様
容量：100ug
Source：Monoclonal Anti-DXD＆Exatecan Antibody, Mouse IgG1 is recombinantly produced from human 293 cells （HEK293）.
