83-3903-84　［取扱停止］HRP conjugated Monoclonal Anti-SN38 Antibody,Mouse IgG1 25ug　SN8-PLS223-25ug

特徴

• 背景
• SN-38 is an antineoplastic drug.
• It is the active metabolite of irinotecan （an analog of camptothecin - a topoisomerase I inhibitor） but has 1000 times more activity than irinotecan itself.
• In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
• SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.
• The variant of UGT1A1 in ～10％ of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form.
• SN-38 and its glucuronide are lost into the bile and intestines.
• It can cause the symptoms of diarrhoea and myelosuppression experienced by ～25％ of the patients administered irinotecan.

仕様

• 容量：25ug
• Source：HRP conjugated Anti-SN38 Antibody, is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with SN38.
• Species Reactivity：Mouse
• Host：Hybridoma
• Tag：Mouse IgG1 | Mouse kappa
• Molecule：SN38
• Format：Powder
• Conjugate：HRP Labeled
• Endotoxin：1.0 EU per μg
• Purity：90％
• Buffer：PBS, pH7.4
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

• 【試薬に関するお問合せ】
• アズワン株式会社 試薬・プロセス材料グループ
• TEL：06-6447-8641
• FAX：06-6447-8642
• E-mail：[email protected]