83-3901-87　Mouse IL-7 Antibody, MouseIgG1 （4C9F12） 1mg　IL7-Y84-1mg

特徴

• 背景
• Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus.
• It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes.
• IL-7 stimulates the differentiation of multipotent （pluripotent） hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage （B cells, T cells and NK cells）.
• It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis.
• IL-7 is a cytokine important for B and T cell development.
• This cytokine and the hepatocyte growth factor （HGF） form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
• IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor.
• Il-7 promotes hematological malignacies （acute lymphoblastic leukemia, T cell lymphoma）.
• Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients.
• IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection.
• IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.