83-3901-69　Anti-Human IL15 （9B5G1） mAb, Mouse IgG1 100ug　IL5-M543-100ug

特徴

• 背景
• Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2.
• Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain （CD122） and the common gamma chain （gamma-C, CD132）.
• IL-15 is secreted by mononuclear phagocytes （and some other cells） following infection by virus（es）.
• This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
• Interleukin 15 （IL-15） regulates T and natural killer （NK） cell activation and proliferation.
• Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15.
• This cytokine is also implicated in NK cell development.
• In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x（L）.
• IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models.
• A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma （kidney cancer） has begun to enroll patients at the National Institutes of Health.