83-3901-10 PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 （AM122） 25tests SPD-PM226-25tests
特徴
- 背景
- It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
- The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
- S1 mainly contains a receptor binding domain （RBD）, which is responsible for recognizing the cell surface receptor.
- S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
仕様
- 容量：25tests
- Source：PE-Labeled Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 （AM122） is a PE-labeled chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 protein. As verified in ELISA, this chimeric monoclonal antibody can bind the spike protein of all SARS-CoV-2 Variants of Concern （VOCs）, including Alpha （B.1.1.7）, Beta （B.1.351）, Gamma （P.1） and Delta （B.1.617.2）.
- Species Reactivity：Mouse
- Host：HEK293
- Tag：Human IgG1 | Human Kappa
- Application：Flow Cytometry （Neutralizing assay）＜p＞Conjugate＜/p＞＜p＞PE＜/p＞＜p＞Excitation Wavelength： 488 nm / 561 nm＜/p＞＜p＞Emission Wavelength： 575 nm＜/p＞
- Molecule：Spike RBD
- Format：Powder
- Conjugate：PE Labeled
- Endotoxin：1.0 EU per μg
- Purity：95％
- Buffer：PBS, pH7.4
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