83-3900-83 Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 （AM122） （MALS verified） 200ug S1N-VM226-200ug
特徴
- 背景
- It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
- The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
- S1 mainly contains a receptor binding domain （RBD）, which is responsible for recognizing the cell surface receptor.
- S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
仕様
- 容量：200ug
- Source：Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 （AM122） （S1N-VM226） is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 Protein. ＜strong＞As verified in competitive ELISA-based and pseudovirus-based neutralization assay, this chimeric monoclonal can potently neutralize all SARS-CoV-2 Variants of Concern （VOCs）, including Alpha （B.1.1.7）, Beta （B.1.351）, Gamma （P.1） and Delta （B.1.617.2）. ＜/strong＞
- Species Reactivity：Mouse
- Host：HEK293
- Tag：Mouse IgG1 ＆ Avi | Mouse Kappa
- Application：This antibody can be paired with other Anti-SARS-CoV-2 Spike S1 antibodies to detect SARS-CoV-2 Spike S1 protein in sandwich ELISA or LFA assay.
- Molecule：Spike RBD
- Format：Powder
- Conjugate：Biotin-labeled
- Endotoxin：1.0 EU per μg
- Purity：95％
- Buffer：PBS, pH7.4
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