Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta.
INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds.
The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain.
Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R.
In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII).
Isoform Short of INSR has a higher affinity for IGFII binding.
When present in a hybrid receptor with IGF1R, INSR binds IGF1.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 107.5 kDa.
The protein migrates as 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Dog Insulin R (28-956) Protein, His Tag (INR-D52H3) is expressed from human 293 cells (HEK293). It contains AA His 28 - Ile 956 (Accession # A0A8I3PWD4).
