The protein encoded by this gene plays a crucial role in B-cell development.
Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.
Alternative splicing results in multiple transcript variants encoding different isoforms.
[provided by RefSeq, Dec 2013]
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 78.2 kDa.
The protein migrates as 55 kDa,65 kDa and 85-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human BTK Protein, His Tag (BTK-H55H3) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ser 659 (Accession # Q06187-1).
Species Reactivity：Human
Host：InsectCells
Tag：C-10×His
Exp Region：Met 1 - Ser 659
Format：Liquid
Conjugate：Unconjugated
Swiss-Prot：Q06187-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris,150 mM NaCl,0.05% Brij-35,1 mM DTT,PH7.5
