This gene encodes a member of the A1 family of peptidases.
The encoded preproprotein is proteolytically processed to generate multiple protein products.
These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme.
This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors.
Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
[provided by RefSeq, Nov 2015]
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 44.5 kDa.
The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human Cathepsin D Protein, His Tag (CAD-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Leu 412 (Accession # P07339-1).
