TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1.
TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA.
Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers.
Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.4 kDa.
The protein migrates as 40-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus TROP-2 Protein, His Tag (TR2-C52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # XP_005543292.2).
