Envelope glycoprotein that forms spikes at the surface of virion envelope.
Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.
Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.
Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 74.3 kDa.
The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：HSV-2 (strain 333) Glycoprotein B (gB), His Tag (GLB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 98 - Ala 730 (Accession # P06763).
