The monoclonal antibody mAb-729 reacts with the human CC chemokine receptor, CCR7.
The protein encoded by this gene is a member of the G protein-coupled receptor family.
This receptor was identified as a gene induced by the Epstein-Barr virus (EBV)，and is thought to be a mediator of EBV effects on B lymphocytes.
This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.
It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation.
The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.
特徴
This protein .
仕様
容量：100ug
Source：Human CCR7 Full Length Protein (VLP) (CC7-H52P3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Pro 378 (Accession # P32248).
