83-3897-30　Human Tyk2 Protein, His Tag 1mg　TY2-H5548-1mg

特徴

• 背景
• Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).
• It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.
• Tyk2 functions primarily in IL-12 and type I-IFN signaling.
• Tyk2 deficiency has more dramatic effects in human cells than in mouse cells.
• However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.
• Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2.
• Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 35.2 kDa.
• The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.