The product of this gene belongs to the integrin alpha chain family.
Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling.
The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit.
This subunit associates with the beta 1 subunit to form a fibronectin receptor.
This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients.
Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
[provided by RefSeq, Oct 2015]
特徴
The protein has a calculated MW of 109.3 kDa & 83.7 kDa.
The protein migrates as 130-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human ITGA5&ITGB1 Heterodimer Protein, Tag Free&Tag Free (IT1-H5214) is expressed from human 293 cells (HEK293). It contains AA Phe 42 - Tyr 995 & Gln 21 - Asp 728 (Accession # P08648-1 & P05556-1).
