The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence.
KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells.
Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
特徴
This protein carries an Avi tag (Avitag) at the N-terminus, followed by a polyhistidine tag.
The protein has a calculated MW of 18.5 kDa.
The protein migrates as 22-25 kDa and 26-31 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Cynomolgus KLRG1 Protein, His,Avitag (KL1-C82Q4) is expressed from human 293 cells (HEK293). It contains AA Leu 60 - Pro 189 (Accession # A0A2K5WAP9).
