Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells.
The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2).
The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα).
Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
特徴
This protein carries a twin strep tag at the C-terminus.
The protein has a calculated MW of 82.6 kDa | 27.6 kDa | 52.6 kDa.
The protein migrates as 33 kDa,120-160 kDa and >180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：HHV-5 (strain AD169) gH&gL&gO, Twin-Strep Tag&Tag Free&His Tag (GLO-H5283) is expressed from human 293 cells (HEK293). It contains AA Arg 24 - Leu 720 & Val 31 - Arg 278 & Lys 31 - Gln 466 (Accession # P12824 & P16832 & P16750).
Species Reactivity：HHV-5
Host：HEK293
Tag：C-Twin Strep | Native | C-10×His
Exp Region：Arg 24 - Leu 720 & Val 31 - Arg 278 & Lys 31 - Gln 466
