83-3896-21　Cynomolgus ASGR1 Protein, Fc Tag 100ug　AS1-C5253-100ug

特徴

• 背景
• This gene encodes a subunit of the asialoglycoprotein receptor.
• This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues.
• The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.
• The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes.
• The protein encoded by this gene is the more abundant major subunit.
• Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• [provided by RefSeq, Jan 2011]
• 特徴
• This protein carries a human IgG1 Fc tag at the N-terminus.
• The protein has a calculated MW of 52.9 kDa.
• The protein migrates as 55 kDa and 60-65 when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.