83-3896-06　［取扱停止］Human Integrin alpha 4 beta 7 （ITGA4＆ITGB7） Heterodimer Protein, His Tag＆Tag Free （MALS verified） 1mg　IT7-H52W5-1mg

特徴

• 背景
• Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 .
• Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid.
• The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT).
• Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs.
• host disease (GVHD).
• 特徴
• Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 59.5 kDa (ITGA4) & 59.4 kDa (ITGB7).
• The protein migrates as 75-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.