83-3895-73　［取扱停止］Biotinylated Human HLA-A*03：01＆B2M＆gp100 （ALLAVGATK） Complex Protein （Monomer, MALS verified） 200ug　HLG-H82E3-200ug

特徴

• 背景
• Glycoprotein 100, is also well known as gp100 and Melanocyte protein PMEL.
• This antigen is a melanocyte-specific type I transmembrane glycoprotein and composed of 661 amino acids.
• Glycoprotein 100 is related to the tumor regression in metastatic melanoma patients after adoptive therapy, by which its epitopes being recognized by tumor lymphocytes and T-cells.
• The gp100280–288(YLEPGPVTA) was originally shown to be recognized by HLA-A*0301 tumor-infiltrating lymphocytes from melanoma patients, and therefore it is widely been studied in TCR -T studies.
• The Human HLA-A*0301 gp100 (YLEPGPVTA) complex protein is a complex of HLA-A*0301 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
• 特徴
• Biotinylated Human HLA-A*03:01&B2M&gp100 (ALLAVGATK) Complex Protein is produced by co-expression of HLA and B2M loaded with gp100 peptide.This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).The protein has a calculated MW of 35.9 kDa and 11.7 kDa.
• The protein migrates as 40-43 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.