Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors.
These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Mutations in this gene are associated with fibrodysplasia ossificans progressive.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 37.9 kDa.
The protein migrates as 43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Activin RIA Protein, Fc Tag (ACA-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 21 - Glu 123 (Accession # Q04771).
