Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
CD8A forms disulfide-linked heterodimers with CD8B at the cell surface.
CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Additionally, CD8B plays a critical role in thymic selection of CD8+ T-cells.
A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.
特徴
Biotinylated Human CD8A&CD8B Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of CD8 alpha and CD8 beta, has a calculated MW of 26.0 kDa (CD8 alpha) and 22.1 kDa (CD8 beta).
Subunit CD8 alpha is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag) and subunit CD8 beta contains no tag but a basic tail at the C-terminus.
The protein migrates as 33 kDa and 35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human CD8A&CD8B Heterodimer Protein, His,Avitag&Tag Free (CDA-H82W7) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Asp 182 (CD8A) & Leu 22 - Pro 170 (CD8B) (Accession # P01732-1 (CD8A) & P10966-1 (CD8B) ).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His & C-Avi | Native
Exp Region：Ser 22 - Asp 182 (CD8A) & Leu 22 - Pro 170 (CD8B)
