Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.
Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues.
This is a strikingly narrow pattern of expression compared with that of other integrins.
Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.The effectiveness of lung transplantation is marred by the relatively high incidence of rejection.
The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7).
This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.
特徴
Cynomolgus ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAE and ITGB7, has a calculated MW of 128.3 kDa (ITGAE) and 81.6 kDa (ITGB7).
The protein migrates as 95-110 kDa and 140-160 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Cynomolgus ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 38 - Ser 1142 & Glu 20 - His 723 (Accession # XP_045231543.1 & XP_005571028.2).
