Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.
Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues.
This is a strikingly narrow pattern of expression compared with that of other integrins.
Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.The effectiveness of lung transplantation is marred by the relatively high incidence of rejection.
The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7).
This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.
特徴
This protein .
The protein has a calculated MW of 127.5 kDa & 81.6 kDa.
The protein migrates as 90-95 kDa,130 kDa and 150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-M53W3) is expressed from CHO cells. It contains AA Phe 20- Val 1114 & Glu 20 - Arg 724 (Accession # Q60677 & P26011).
