Orphan nuclear receptor 4A1(NR4A1) belongs to the NR4A superfamily and plays an important role in inflammation, cell metabolism, proliferation and differentiation.
NR4A1 expression can be induced by various stimuli in macrophages.
NR4A1 has a bidirectional effect of inhibiting or promoting the inflammatory response of atherosclerosis (AS), which may be related to the different microenvironment, cell phenotype and transfection vector.
NR4A1 can promote pathological angiogenesis, which is an important factor affecting plaque instability.
The role of NR4A1 in inflammation and pathological angiogenesis of AS was reviewed, in order to provide a target for the treatment of stable plaque and provide a reference for the prevention and treatment of AS.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 29.5 kDa.
The protein migrates as 25 kDa and 29-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Nr4a1 Protein, His Tag (NR1-H5144) is expressed from E. coli cells. It contains AA Ser 351 - Phe 598 (Accession # P22736-1).
