50% of cancers carry a TP53 mutation while many others affect other pathway components.
High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells.
The Human HLA-A*0201 p53 (GLAPPQHLIRV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and GLAPPQHLIRV peptide of the p53.
特徴
PE-Labeled Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Tetramer Protein is assembled by biotinylated monomer (HLP-H82Eb) and PE-labeled streptavidin.Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide.
Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
仕様
容量：25ug
Source：PE-Labeled Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Tetramer Protein (HLP-HP2Hc) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide (Accession # AAA59600.1 (HLA-A*24:02) & P61769 (B2M) & TYSPALNKMF).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His
Exp Region：Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide
