50% of cancers carry a TP53 mutation while many others affect other pathway components.
High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells.
The Human HLA-A*0201 p53 (GLAPPQHLIRV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and GLAPPQHLIRV peptide of the p53.
特徴
Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide.This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).The protein has a calculated MW of 35.8 kDa and 11.7 kDa.
The protein migrates as 39-42 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (HLP-H82Eb) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide (Accession # AAA59600.1 (HLA-A*24:02) & P61769 (B2M) TYSPALNKMF).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His & C-Avi
Exp Region：Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide
