The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I.
The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis.
Elevated plasma levels of this protein are linked to atherosclerosis.
Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains.
The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.
[provided by RefSeq, Dec 2009]
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 226.3 kDa.
The protein migrates as >250 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human LPA Protein, His Tag (LPA-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 20 - Asn 2040 (Accession # P08519).
