Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).
In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells.
CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 19.6 kDa.
The protein migrates as 20-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus CD8 alpha Protein, His Tag (CDA-C52H4) is expressed from human 293 cells (HEK293). It contains AA Asn 63 - Asp 223 (Accession # XP_005575419.2).
