83-3892-87　［取扱停止］Human HLA-A*02：01＆B2M＆PRAME （SLLQHLIGL） Tetramer Protein （MALS verified） 25ug　HLE-H52H9-25ug

特徴

• 背景
• This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes.
• It is not expressed in normal tissues, except testis.
• The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function.
• Alternative splicing results in multiple transcript variants.
• The PRAME (SLLQHLIGL) was shown to be recognized by HLA-A*0201 tumor-infiltrating lymphocytes from melanoma patients, and therefore it is widely been studied in TCR-T studies.
• The Human HLA-A*0201 PRAME (SLLQHLIGL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M and PRAME (SLLQHLIGL) peptide.
• 特徴
• Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein is assembled by biotinylated monomer (HLE-H82E8) and streptavidin.Biotinylated Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Complex Protein is produced by co-expression of HLA and B2M loaded with PRAME peptide.
• Biotinylated Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).The protein has a calculated MW of 51.3 kDa and 13.8 kDa.
• The protein migrates as 55-60 kDa and 12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.