83-3892-83　Human OX40 Ligand / TNFSF4 Protein, His Tag, active trimer （MALS verified） 50ug　OXL-H5243-50ug

特徴

• 背景
• Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family.
• TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
• The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer.
• Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer.
• Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 49.4 kDa.
• The protein migrates as 50-116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.