50% of cancers carry a TP53 mutation while many others affect other pathway components.
High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells.
The Human HLA-A*0201 p53 (HMTEVVRHC) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and HMTEVVRHC peptide of the p53.
特徴
PE-Labeled Human HLA-A*02:01&B2M&p53 (HMTEVVRHC) Tetramer Protein is assembled by biotinylated monomer (HLP-H82E3) and PE-labeled streptavidin.Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRHC) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide.
Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRHC) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
仕様
容量：200ug
Source：PE-Labeled Human HLA-A*02:01&B2M&p53 (HMTEVVRHC) Tetramer Protein (HLP-HP2H6) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRHC peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & HMTEVVRHC).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His
Exp Region：Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRHC peptide
