This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose.
Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load.
Defect in this gene thus may contribute to the pathogenesis of diabetes.
[provided by RefSeq, Oct 2011]
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 16.6 kDa.
The protein migrates as 21-31 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human GIPR Protein, His,Avitag (GIR-H82E3) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Gln 138 (Accession # P48546-1).
