Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are considered to be constitutively active kinases.
This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
特徴
This protein .
The protein has a calculated MW of 37 kDa & 39.1 kDa.
The protein migrates as 80-95 kDa and >150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag (ACB-H5253) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Glu 126 & Gly 20 - Pro 133 (Accession # P36896-1 & Q13705-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc | C-Fc
Exp Region：Gly 25 - Glu 126 & Gly 20 - Pro 133
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P36896-1 | Q13705-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
