Herpesvirus infections are widely spread throughout the world population.
Herpes simplex virus (HSV) belongs to the α-herpesvirus subfamily.
There are two main types of HSV, HSV-1 and HSV-2, which infect humans.
HSV-2 mainly causes genital lesions, whereas HSV-1 is involved in both oral and genital infections.
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.
Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.
Implicated in basolateral spread in polarized cells.
In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.
特徴
This protein .
The protein has a calculated MW of 76.0 kDa.
The protein migrates as 80-90 kDa and 93 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Rubella virus Glycoprotein E2 & E1 (strain M33) (RUBV), His Tag&Strep II Tag (GL2-R5583) is expressed from Baculovirus-Insect cells. It contains AA Gly 301 - Ala 532 & Glu 583 - Ala 1026 (Accession # P08563).
