Matrix metalloproteinase-8（MMP-8）also known as neutrophil collagenase and CLG1，is a member of matrix metalloproteinases (MMPs) family，which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes.
MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development.
MMP-8 in the tumor may have a protective effect against lymph node metastasis.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.0 kDa.
The protein migrates as 38-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human MMP-8 Protein, His Tag (MM8-H52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 262 (Accession # P22894-1). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.
