This gene encodes a subunit of the asialoglycoprotein receptor.
This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues.
The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.
The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes.
The protein encoded by this gene is the more abundant major subunit.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
[provided by RefSeq, Jan 2011]
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 52.2 kDa.
The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse ASGR1 Protein, Fc Tag (AS1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 61 - Asn 284 (Accession # P34927).
Species Reactivity：Mouse
Host：HEK293
Tag：N-Fc
Exp Region：Gln 61 - Asn 284
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P34927
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5
