Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators.
PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes.
PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family.
PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ.
PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines.
PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.
In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.
Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 43.0 kDa.
The protein migrates as 57-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse PD-1 Protein, Mouse IgG2a Fc Tag (PD1-M5257) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # Q02242-1).
