Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684).Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).Enhances cytokine production in macrophages and dendritic cells (By similarity).Mediates production of reactive oxygen species in the cell (By similarity).Mediates phagocytosis of C.albicans conidia (PubMed:17230442).Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation.
Stimulates T-cell proliferation.
Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.5 kDa.
The protein migrates as 15-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human CLEC7A Protein, His Tag (CL7-H5248) is expressed from human 293 cells (HEK293). It contains AA Thr 66 - Met 201 (Accession # NP_072092).
