FUS (RNA-binding protein FUS) is a DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response.
It binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing.
It binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay.FUS plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair.
In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 97.0 kDa.
The protein migrates as 95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human FUS Protein, His Tag (FUS-H5144) is expressed from E. coli cells. It contains AA Met 1 - Tyr 526 (Accession # P35637-1).
