The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12.
IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212.
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
Associated with IL12RB2 it forms a functional, high affinity receptor for IL12.
Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 83.9 kDa.
The protein migrates as 110-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus IL-12 R beta 1 Protein, Fc Tag (ILB-C5253) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Asp 545 (Accession # G7PWY9-1).
