83-3891-03　Mouse GUCY2C / Guanylyl cyclase C Protein, His Tag （MALS verified） 1mg　GUC-M53H5-1mg

特徴

• 背景
• GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP.
• Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury.
• GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C.
• Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 49.0 kDa.
• The protein migrates as 80-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.