The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure.
We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs.
Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 62.0 kDa.
The protein migrates as 80-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Cynomolgus Siglec-10 Protein, His,Avitag (SI0-C82E5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # XP_005590164.1).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：C-10×His & C-Avi
Exp Region：Thr 17 - Ala 549
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：A0A2K5WBX8-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0
