Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135.
FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III.
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.
Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.
Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.
Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 59.9 kDa.
The protein migrates as >85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus Flt-3 Protein, His Tag (FL3-C52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Ser 541 (Accession # A0A2K5VQ48).
