Nectin-4(Nectin cell adhesion molecule 4) is a Nectin and nectin-like family of cell adhesion molecules.
It is found in high levels in normal embryonic and fetal tissues, but decreases after adulthood and is limited in distribution in healthy tissues.
Nectin-4 is overexpressed in a variety of tumor cells and promotes tumor cell growth and proliferation.
Solid tumors with high expression of Nectin-4 include bladder cancer, pancreatic cancer, triple negative breast cancer, non-small cell lung cancer, stomach cancer, esophageal cancer, ovarian cancer and many other cancers.
Studies have found that Nectin-4 promotes tumor cell proliferation, differentiation, migration and invasion by activating the PI3K/Akt pathway, and is believed to play an important role in the occurrence and metastasis of cancer.
It is based on these research backgrounds that drug research targeting this target has emerged.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 62.2 kDa.
The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human Nectin-4 Protein, Fc,Avitag (NE4-H82F4) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Gly 32 - Ser 349
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q96NY8-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
