Fibroblast growth factor-4 (FGF4) is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions.
Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers.
In lung adenocarcinoma (ADC) cell lines, FGF4 could alter cell morphology, promote epithelial-mesenchymal transition-associated protein expression, and enhance cell proliferation, migration/invasion and colony initiation.
In B-cell lymphoma, FGF4 secretion by cancer cells induces Jag1 expression in neighbor Endothelial cell that in turn activates Notch2 in lymphoma cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 19.8 kDa.
The protein migrates as 23-24 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human FGF-4 Protein, His Tag (FG4-H51H3) is expressed from E. coli cells. It contains AA Ser 54 - Leu 206 (Accession # P08620-1).
