This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions.
The family members have distinct substrate specificities and tissue-specific expression patterns.
The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function.
This enzyme may also play a role in hair follicle formation.
This gene exists in a cluster with four other paralogous genes.
[provided by RefSeq, Jul 2008]
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 76.7 kDa.
The protein migrates as 47 kDa and 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human PADI1 Protein, His Tag (PA1-H5543) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Pro 663 (Accession # Q9ULC6).
