Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL.
Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals.
IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated.
dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 81.6 kDa.
The protein migrates as 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse IL-31 RA Protein, Fc Tag (ILA-M5254) is expressed from human 293 cells (HEK293). It contains AA Val 19 - Thr 499 (Accession # Q8K5B1-1).
